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- The general adaptation syndrome and the diseases of adaptation
- Scholarly Journal of Emergency Medicine and Critical Care
- Hans Selye
- What to know about general adaptation syndrome
The general adaptation syndrome and the diseases of adaptation
The term of general adaptation syndrome was coined by Hans Selye — , an Austro-Hungarian endocrinologist. Selye worked at McGill University in Montreal when he made his initial and somewhat serendipitous observations. In a pursuit of identifying novel sex hormones, he discovered that ovarian extracts administered to rats evoked a triad of pathologic changes adrenal enlargement, thymo-lymphatic tissue atrophy, and gastrointestinal ulcerations. Intriguingly, administration of placental, pituitary, and other tissue extracts as well as a large variety of physical and chemical irritants induced similar changes. In , Selye published his early Skip to main content Skip to table of contents.
Scholarly Journal of Emergency Medicine and Critical Care
Accepted: June 04, Published Online: June 06, Louis Pasteur played a major part in the discovery of microorganisms, particularly those that affect health. He is purported to have said on his deathbed "I was wrong: It is the terrain that matters". He meant, of course, the natural defenses with which the human body is equipped. All members of the animal kingdom live in a hostile environment, the major contributors being the microorganisms that result in disease.
Although he did not recognize all of the many aspects of glucocorticoids , Selye was aware of their role in the stress response. Charlotte Gerson  considers him the first to demonstrate the existence of biological stress. He was nominated for the Nobel Prize in Physiology or Medicine for the first time in Although he received a total of 17 nominations in his career, he never won the prize. Selye died on October 16, in Montreal, Quebec , Canada. He often returned to visit Hungary, giving lectures as well as interviews in Hungarian television programs. He conducted a lecture in at the Hungarian Scientific Academy in Hungarian and observers noted that he had no accent, despite spending many years abroad.
It is becoming increasingly more obvious that certain physiologic mechanisms, in which the endocrin system plays a prominent part, help to raise resistance to damage as such, irrespective of the specific nature of the damaging agents. Interest in the general adaptation syndrome has recently received a further impetus as a result of investigations suggesting that some of the most important diseases of human pathology such as hypertension, nephrosclerosis and the rheumatic diseases may represent by-products of the endocrine reactions, which are at play in the general adaptation syndrome. It was considered a timely enterprise, therefore, to survey this field now and to supply a guide to the rather scattered and polyglot, pertinent literature. In order to familiarize himself with different points of view, the reader is also referred to several earlier reviews on the general adaptation syndrome 10, 11, , , , , , , , , Most users should sign in with their email address. If you originally registered with a username please use that to sign in.
Responses to stress ; Stress reactivity. It refers to the nonspecific, generalized responses of the body in response to stress and provides a framework for the link between stress and chronic illness Selye, This syndrome is divided into three stages: alarm reaction, resistance, and exhaustion. In an experiment designed to discover a new hormone, he injected Skip to main content Skip to table of contents.
What to know about general adaptation syndrome
He gave rats daily injections of ovarian extract and found that the rats had enlarged adrenals and shrunken spleens, thymus, lymph nodes, and intestinal ulcers. Evan-Martin, In , Selye defined these series of symptoms in the experiments with the rats as the General Adaptation Syndrome , which consists of three stages: the alarm stage, the resistance stage, and the exhaustion stage Evan-Martin, The alarm stage is similar to the fight-to-flight response, and the body mobilizes resources to react to the incoming noxious agent.
Но все доказательства к этому моменту будут уничтожены, и Стратмор сможет сказать, что не знает, о чем речь. Бесконечная работа компьютера. Невзламываемый шифр. Но это полный абсурд.